As presented at the TMPred web-service (http://www.ch.embnet.org/software/TMPRED_form.html): “The TMPred (Transmembrane Predictor) makes a prediction of membrane-spanning regions and their orientation. The algorithm is based on the statistical analysis of TMbase, a database of naturally occurring transmembrane proteins. The prediction is made using a combination of several weight-matrices for scoring”. This project offers a C++11 updated off-line version of TMPred for fasta files. Also, our version allows to modified all the internal parameters use by TMPred to detect transmembranes. For more information of how TMPred works please refer to http://www.ch.embnet.org/software/tmbase/TMBASE_doc.html